Preimplantation genetic testing for aneuploidy: A Canadian Fertility and Andrology Society Guideline

The objective of this guideline from the Canadian Fertility and Andrology Society is to synthesize evidence on preimplantation genetic testing for aneuploidies (PGT-A) using trophectoderm biopsy 24-chromosome analysis provide clinical recommendations Grading Recommendations Assessment, Development Evaluation (GRADE) framework. To date, randomized controlled trials have been limited good-prognosis patients who were able generate two or more blastocysts biopsy. In specific population GRADE PGT-A shows an increase in implantation rate ongoing pregnancy delivery per transfer. Clearly, it difficult generalize subgroup infertility at large. As a result, application should be individualized, patient factors such as age ability embryos will influence decision-making. Comprehensive counselling informed consent are imperative before undertaking PGT-A. Potential benefits must weighed against costs limitations technology, including risk embryo damage, false positives, negatives detection embryonic mosaicism. Future research required, especially with regard use poorer prognosis patients, respect reporting outcomes cycle start cumulatively retrieval.